genophoria.bsky.social
Core Investigator @ Arc Institute | Associate Professor @ UCSF | {Computational, Systems, Cancer, RNA} biologist | Co-founder @exaibio @vevo_ai
👤 Joined on 03 August 2023
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@genophoria.bsky.socialHundreds of human tRNA genes form a redundant repertoire for decoding the genetic code. But does redundancy imply functional equivalence? A pan-cancer in vivo CRISPRi atlas from @genophoria.bsky.social and Vijay Ramani at @Gladstone Institutes reveals a structured landscape of tRNA dependencies.
Show PostThe code is on GitHub, with model checkpoints and data on Hugging Face. Learn more about PIE from co-authors Rishi Verma and @genophoria.bsky.social: arcinstitute.org/news/pie Or access the preprint: www.biorxiv.org/content/10.6...
Show PostI did read it before commenting! Evaluating “informed” vs. pathological failures is nontrivial. Being “informed” isn’t always good — cf. statistical NLP and the Bitter Lesson. Until @genophoria.bsky.social talk last Wednesday I’d seen little evidence of a complex models beating simple baselines
Show PostSee the full announcement from program organizer @genophoria.bsky.social: arcinstitute.org/news/aixbio-... :
Show PostThank you Mark Foundation (@themarkfdn.bsky.social) for supporting our founder Hani Goodarzi (@genophoria.bsky.social) and team on his paper about our novel oncRNA biology. This research is foundational to Exai Bio where we develop AI models targeting oncRNAs to detect disease earlier.
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