TEDLH is now searchable online! Paste your protein sequence and detect remote homologues across 4,600+ CATH superfamilies. Results are annotated and linked to experimentally determined PDB structures. Give it a try! 🔗 tedlh-cs.cathdb.info #Bioinformatics #ProteinStructure @cathgene3d.bsky.social

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Now in The Plant Cell: doi.org/10.1093/plce... We pulled together studies from Arabidopsis, rice, maize, barley, soybean and wheat to propose a cellular framework of seed dev through to germination, and to show what is conserved/differs. With Cunman He, @lewseylab.bsky.social, and James Whelan.

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Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

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IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

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This is a truly startling paper. It shows that mRNA can perform regulatory functions *in addition to* its role in encoding a protein. In other words, the distinction between protein-coding RNA and noncoding regulatory RNA is fuzzy. /1 www.science.org/doi/10.1126/...

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