Cedric Boeckx

cedricboeckx.bsky.social

14 February 2026 11:31

Very nice work led @drghawkes.bsky.social, showing convergence between rare and common genetic associations, using whole-genome sequencing data to evaluate the contribution of rare non-coding variants for commonly studied anthropometric traits 🧪🧬 www.nature.com/articles/s41...

Kartik Chundru

chundru.bsky.social

06 February 2026 11:13

Woo!!! @hiwwright.bsky.social bamboozles us with his All of Us mastery! This is the result of lot of hard work and some brilliance from one of the most talented ECRs I’ve worked with A very important message which will reduce a lot of noise in aggregate associations, and improve interpretability

Harry Wright

hiwwright.bsky.social

06 February 2026 11:13

Excited to share my first preprint on federated conditional analysis of rare single variant and aggregate association tests across six genetically-inferred ancestry groups in All of Us and UK Biobank doi.org/10.64898/202...

Harry Wright

hiwwright.bsky.social

06 February 2026 09:39

Massive thanks to everyone involved in this study, @chundru.bsky.social @drarwood.bsky.social @carolinefwright.bsky.social @laferrat.bsky.social @rnbeaumont.bsky.social @mnweedon.bsky.social @kash-a-patel.bsky.social @drghawkes.bsky.social @timfrayling.bsky.social Liza Darrous and Aurelie Kamoun

Harry Wright

hiwwright.bsky.social

06 February 2026 09:38

This is because rare variants and aggregates are confounded by linkage and haplotype structure, just like common variant GWAS. Previous methods which rely on reference panels or LD-matrices to determine independence break down or don't scale to very rare variants in WGS data