jychoi.bsky.social
Assistant professor of evolutionary genomics at KU. Has a toddler 🙂🙃🙂🙃🇰🇷🇨🇦🇺🇲 https://jychoilab.github.io/
👤 Joined on 27 February 2024
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@jychoi.bsky.socialNew preprint 📄 Should long-read RNA-seq counts be normalized? We benchmarked 5 normalization methods × 5 quantifiers on PacBio and ONT, using spike-ins and matched Illumina as ground truth 🧵 www.biorxiv.org/content/10.6...
Show PostWe got the cover! Way to go @jillmlove.bsky.social !!!!!
Show PostPhylogenetic conservation scores have long been used to identify selection targets in the genome. With machine learning, they take a new form and will likely grow in popularity. @apragsdale.bsky.social and I investigate their relationship with mutation rates www.biorxiv.org/content/10.6...
Show PostResearch is full of uncertainty, but every once in a while, nature works out exactly as you hypothesized. In 2019, while finishing my PhD, I pitched a bold idea in an email to @harmitmalik.bsky.social (below). Seven years later, it feels surreal to see that hypothesis become empirical reality. 🧵👇
Show PostThrilled to share that our paper is finally out in Science Advances! 🔗 www.science.org/doi/10.1126/... TL;DR: A Drosophila protamine acts as shields resolving conflict between X and Y chromosomes. Disruption unleashes meiotic drive that kills X-bearing sperm and skews progeny sex ratios. 🪰🧬ᯡ
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