masakanai.bsky.social
Instructor in Medicine, MGH / HMS / Broad Institute https://mkanai.github.io/
👤 Joined on 26 August 2023
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@mkanai.bsky.social@mkanai.bsky.social → @masakanai.bsky.socialA new immune atlas reveals how disease-associated gene variants actually cause disease. Our Vice Director, Ramnik Xavier and Mark Daly co-led the team that built the atlas by analyzing 1000s of genes from a large-scale study, now @nature.com. www.nature.com/articles/s41...
Show PostVery cool @nature.com study led by @masakanai.bsky.social tackling the very difficult problem of going from variants to disease-relevant regulatory mechanisms 🧪🧬 👇
Show PostUsing data from more than 1,100 Finnish blood donors participating in FinnGen, @masakanai.bsky.social and colleagues have created an atlas of over 10 million immune cells that links disease-associated genetic variants to the genes they control. The findings were just published in @nature.com.
Show PostThis is consistent with the enhancer domain score work, showing that regions exhibiting constraint have more complex regulatory landscapes! Very cool!
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