Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

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Order Matters: Ambient RNA correction confounds doublet detection in single-cell RNA sequencing https://www.biorxiv.org/content/10.64898/2026.10.13.758369v1

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The human gut microbiome primes fever after vaccination | Science www.science.org/doi/10.1126/...

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How does gene expression change during regeneration? Are specific enhancers activated or is there extensive genome re-modelling? Working with the team of Guillermo Orsi, we show that insect (cricket) and crustacean (Parhyale) genomes become re-modelled on a genome-wide scale.

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1,000 years from now, teachers will struggle to explain to their students how at this time in history, we found literally the most despicable human being in America and made him the most powerful person in the world

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