In a new review on DADA2, @isabellemeyts.bsky.social et al. cover the full spectrum of disease (#vasculitis, bone marrow failure, #immunodeficiency), TNF inhibitors, stem cell transplant, & #genetherapy on the horizon, the concept that a single variant can cause disease. rupress.org/jhi/article/...

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Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach. Read the full report: https://nej.md/3Rlv5Sm

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Enzymatic degradation of NETs can rapidly ameliorate clinical manifestations of severe, treatment-refractory SLE in a patient with congenital DNASE1L3 deficiency www.nejm.org/doi/full/10.... @nejm.org

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Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

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Paul Bastard, MD, PhD, and Jean-Laurent Casanova, MD, PhD, describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease. Read the editorial: https://nej.md/4e1EZ4s

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