Kermit Murray

kkmurray.bsky.social

15 September 2026 22:43

Cryo-EM sample preparation with soft-landing and laser flash melting #nature #MassSpecRSS

asher newsome

iondoctor.bsky.social

08 August 2026 02:58

They made @acs.org journals so horrible to look at on a desktop screen that they are now using the pop-up to obscure the mobile view with the x cut off so you can't close it

bskytdp.bsky.social

07 August 2026 15:00

Yes, this is why time-to-sampling after death & how the body is maintained during that period are so critical (but too often ignored). The errors on some clinical data that comes from the 'any old' postmortem sample approach are appalling & essentially meaningless....& that's aside from/before MS!

bskytdp.bsky.social

07 August 2026 14:25

Definitely, & why sample handling/prep is so critical yet often ignored. Makes one seriously concerned with what's in all the biobanks & what analyses of those samples really teaches us! But let me ask you what you would do? I'm not sure about 'instantly' degrading though...what's the evidence?

bskytdp.bsky.social

07 August 2026 13:57

High res front-end separation before LC-MS/MS (i.e. iTDP). The 'issue' is: it's not fast. The idea that proteomics should be as 'fast' as gene sequencing is (currently) a ridiculous dogma considering proteome complexity. But shotgun gets data & papers - publish or parish trumps analytical depth.