James Briscoe

jamesbriscoe.bsky.social

17 October 2026 03:03

New commentary from the lab - can we identify principles of transcriptional regulation & cis-regulatory element (CRE) control of gene expression? With @jcornwallscoones.bsky.social & @joadelas.bsky.social in @cp-molcell.bsky.social A thread 🧵 doi.org/10.1016/j.mo...

Evgeny Kvon

evgenykvon.bsky.social

16 October 2026 01:36

Our Department of Developmental & Cell Biology @ucirvine.bsky.social is looking for a Professor & Chair! Join our diverse and collegial team in the premier UC public system. Dept: devcell.bio.uci.edu Details: recruit.ap.uci.edu/JPF10452

Evgeny Kvon

evgenykvon.bsky.social

15 October 2026 07:47

Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

Evgeny Kvon

evgenykvon.bsky.social

30 September 2026 16:54

This is a really cool finding, congrats! It also reminds me of a recent paper from John Lis's lab showing that LTR promoter transcription in the NMU enhancer attenuates its activity: pubmed.ncbi.nlm.nih.gov/42468524/. So it appears to be a broader mechanism?

Evgeny Kvon

evgenykvon.bsky.social

19 September 2026 19:18

G&D was the journal that made me fall in love with developmental genetics in college. Incredibly lucky my first grad paper was published there. Terri was the editor and accepted it after the 1st round which gave me so much optimism starting out. We’re lucky to have had her. RIP