Oscar Chadney

oscar-chadney.bsky.social

13 July 2026 15:17

Thanks! That’s a great question. I would speculate that a novel context induces changes in ECII (as in www.biorxiv.org/content/10.1...), which provide the input for DG to perform pattern separation or generate a novelty signal (www.nature.com/articles/s41...), driving CA3 into a new attractor state

Oscar Chadney

oscar-chadney.bsky.social

13 July 2026 15:17

CA1 would then compare this retrieved CA3 representation with ongoing sensory/contextual input from ECIII to determine whether a new map should be established. Broadly in line with mismatch/comparator theories and the contextual gating hypothesis

Matteo Guardamagna

matteoguardamagna.bsky.social

09 July 2026 16:34

🚨 New preprint! How do CA1 place cells build a brand-new spatial map when the animal enters a novel environment? We combined ensemble recordings with optogenetic silencing of direct entorhinal input to CA1, to uncover this pathway's role in remapping. Thread from Oscar below! 🐭

Sam Gershman

gershbrain.bsky.social

09 July 2026 16:17

There are several problems with Skinner. First, for someone so preoccupied with scientific rigor, it's ironic that a 450 page book about human behavior doesn't mention a single study of humans. It's all extrapolation from studies of pigeons and rats, interwoven with anecdotes.

Sam Gershman

gershbrain.bsky.social

09 July 2026 16:16

I've seen attempts to rehabilitate BF Skinner, arguing that he was unfairly maligned (most famously by Chomsky), that he was caricatured by cognitive scientists. I was surprised to hear even Josh Tenenbaum say that Skinner wasn't so bad. So I picked up "Science and Human Behavior" to see for myself.