Centre for Academic Primary Care (CAPC), Bristol

capcbristol.bsky.social

29 July 2026 12:29

Portable HEPA filters made no difference to rates of respiratory and other infections in older people’s care homes, finds new @nihr.bsky.social funded research published in @jamainternalmed.com. Care homes should continue with standard infection control, including vaccines. 👉 tinyurl.com/bdhe42bn

Denis - The COVID Info Guy

thecovidinfoguy.bsky.social

27 July 2026 23:15

US Weekly COVID update: July 27, 2026 🔸1 in 198 Actively Infectious 🔸247,000 Daily Infections 🔸1,570,000 Infections In The Past Week 🔸89,000,000 Infections in 2026 🔸79,000 to 310,000 Weekly Long COVID Cases 🔸400 to 700 Weekly Excess Deaths Source: pmc19.com

Edward Nirenberg

enirenberg.bsky.social

27 July 2026 22:30

but to generate clinically meaningful effects, we require suprathreshold signaling that vaccines can provide. The thing is, these signals are not specific to vaccines. We see them with infections, too. For example, high levels of IL-6 can imprint a pro-inflammatory signature on...

Edward Nirenberg

enirenberg.bsky.social

27 July 2026 22:30

But then, when you consider live attenuated vaccines, the nature of the immune response induced by them should be very similar to that of the native infection they protect against. That leads us to another possibility: 2. Both vaccines and our commensal microbes can enable trained immunity...

Edward Nirenberg

enirenberg.bsky.social

27 July 2026 22:30

There is some plausibility to at least parts of this. For example, we have seen that commensal strains of E. coli have a flagellin (a family of proteins that help bacteria swim via tail-like structures) that can bind to TLR5 (the key sensor of flagellin) without triggering signaling.