From MBoC: What helps cells stay connected as they move together to shape tissues? A Drosophila study identified 22 genes involved in testis morphogenesis and uncovered new roles for Par-1 and RN-tre in cell migration and tissue organization. https://www.molbiolcell.org/doi/10.1091/mbc.E26-05-0234

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@joethorntonlab.bsky.social and I are thrilled to co-organize the 2027 Molecular Mechanisms in Evolution GRC, June 13–18, in beautiful Portland, Maine! See our ⭐stellar⭐ lineup of speakers ⬇️ spanning evolutionary biochemistry, cell biology, development, behavior... www.grc.org/molecular-me... 1/n

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This week we just had a lab retreat where we connect over fun activities, discussion about lab values, and hiking (with some mushroom and soil sample collection). I’m so grateful to be part of the lab and make all this happen with a group of supportive colleagues!

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Our lab is obsessed by hidden biology - protein products central to understanding how our cells function, but missing from standard genome annotations. Introducing new work from post-doc Eric Smith on alternative translational isoforms for heterochromatin protein 1. www.biorxiv.org/content/10.6...

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🚨🚨Preprint alert!🚨🚨 We removed the main centromere 3 domain of Drosophila‼️ We designed an inducible dCas9-Fok1 system to cut 🧬 at unique sequences flanking the ~50-kb island where most of CENP-A sits. To our knowledge, this has never been attempted in a living animal!

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