Giulia Palermo

giuliapalermo.bsky.social

20 October 2026 01:54

🚀Excited to share our new paper #NatureCommunications 🎉! We uncover a 🧨 #CrypticPocket in #CRISPR #Cas9 that forms transiently on super short timescales not trapped by #cryoEM! 🧬This pocket enables metal ions to regulate #DNA cleavage! 🔗 hhttps://www.nature.com/articles/s41467-026-78458-0

RCSB Protein Data Bank

rcsbpdb.bsky.social

16 October 2026 18:01

The PDB50 board game was created to celebrates the anniversary of the PDB by giving players the opportunity to explore the process of structure discovery. Download or play online to celebrate the PDB's 55th anniversary

Leslie B Vosshall PhD

leslievosshall.bsky.social

15 October 2026 03:28

Not one, not two, but three insect ionotropic receptor CryoEM structures from @hhmi-science.bsky.social #FreemanHrabowski Scholar Josefina del Marmol: biorxiv.org/content/10.6... Read this pre-print for the full picture of IR structure-function.

Steve Bonilla

steve-bonilla.bsky.social

15 October 2026 02:02

Check the preprint of our exciting collaboration with @pilarcossio.bsky.social and others: Quantifying RNA Folding Equilibria from Unclassfied Cryo-EM Images biorxiv.org/content/10.6... see Pilar's very nice description. Congrats Deb Maji and team!

pilarcossio.bsky.social

14 October 2026 21:18

1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion. At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria? New preprint: yes, straight from the raw particle images👇