siegel-lab.bsky.social
We use T. brucei to study the role of chromatin and genome architecture in antigenic variation. https://www.vetmed.lmu.de/molpara/en/
👤 Joined on 15 November 2024
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@siegel-lab.bsky.socialNature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto www.nature.com/articles/s41...
Show Post🥳 I still can’t quite believe this is real: I’ve been awarded a Marie Skłodowska-Curie Postdoctoral Fellowship (#MSCA) with a 100% evaluation score. Excited for what’s ahead at @lmu.de (@bmc-lmu.bsky.social) in the @siegel-lab.bsky.social ✨
Show Post𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Show PostNew on bioRxiv! Our manuscript shows how the methyltransferase PCKMT primes the conoid by retaining Formin1 for motility initiation in Toxoplasma gondii, working with AKMT to activate the parasite’s motility machinery. #Toxoplasma #Apicomplexa #Methylation #ParasiteMotility
Show PostICYMI: Evaluation and prediction of guide RNA activities in genome-editing tools
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