jhschaef.bsky.social
Structural Biology to the rescue. Postdoc at Scripps Research. https://jhschaefer.de/ ❄️🔬 🎹⛳
👤 Joined on 14 November 2024
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@jhschaef.bsky.socialStruggling to choose a pixel size for your cryo-ET acquisition? Worry not: super-resolution processing can take in situ subtomogram averaging beyond physical Nyquist! We reached 2.8 A loc-res of a ribosome dataset with 4.78 A physical Nyquist limit! Our new preprint 👇: doi.org/10.64898/202...
Show PostAdded something to chimerax-trimmings that I have wanted for ages! Added old Chimera-style model controls, so that one can freeze or activate specific models and freely rotate/translate them with respect to one another. Implemented as modelmotion in latest version. github.com/olibclarke/c...
Show Post1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion. At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria? New preprint: yes, straight from the raw particle images👇
Show PostI hear so much about the growing power of predictive biology, especially in drug discovery and "co-folding". I want to see people put their GPU budget where their mouth is!
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