Matt Howard

matthewkhoward.bsky.social

20 October 2026 12:38

🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

Alex Merz 🇺🇸🇨🇦🇺🇦

merz.bsky.social

11 October 2026 09:33

This is jaw-dropping.

Doug Kojetin

dougkojetin.bsky.social

11 October 2026 09:32

Apply today to be my colleague at Vanderbilt in the Department of Biochemistry! 

James Fraser

fraserlab.com

10 October 2026 20:33

Come be my colleague at UCSF! Our department BTS (like the K-pop band, but aka Bioengineering and Therapeutic Sciences) is searching for TWO new faculty members. Links, timeline, and why two searches in this thread 🧵

James Fraser

fraserlab.com

10 October 2026 20:25

Given a ligand SMILES and nothing else, predict the 3D structure of the CYP3A4 complex. DO IT!!! CYP CYP Hooray!