Can protecting the cell nucleus prevent heart failure—even when the genetic defect remains? Our new study in @CircRes suggests it can! We identify nuclear envelope rupture as a key driver of LMNA-related cardiomyopathy. 1/7 doi.org/10.1161/CIRC... #Mechanobiology, #lamins, #LMNA

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Mutations in the LMNA gene, encoding nuclear lamins A/C, cause severe dilated cardiomyopathy. But what drives the disease? Perturbed chromatin organization/gene regulation or mechanical damage to the nucleus? Distinguishing these mechanisms is critical for developing new therapies. 2/7

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If you like this thread, please check out my Substack, where I post more thoughts like this in longer form, and follow me on all social and video platforms. ryanarey.substack.com

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It’s worth pointing out that the one thing you never see in these news stories about the “doubts about vaccine safety” is any real world evidence that vaccines are unsafe or causing harms

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In a new edition of ACC's Cardiology Hour, Dr. Valentin Fuster & a panel of experts break down the top late-breaking clinical trials released during #ESCCongress, such as NOTION-4, SINGLE-AF, & more! 📽️: https://bit.ly/4zOTxNn @accintouch.bsky.social #JACC #CardioSky

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