How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2

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Join us on May 4 for Biochemistry Colloquium with Benjamin Garcia. The @garcialabms.bsky.social is focused on developing & applying quantitative mass spectrometry-based proteomics & related computation for understanding dynamic protein & proteome PTMs. More info: today.wisc.edu/events/view/...

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Award and abstract submissions due April 20! Join FASEB for #BioMethylSRC! Featuring speakers @garcialabms.bsky.social and @metorrespadilla.bsky.social alongside organizers @brianstrahl.bsky.social, @vanrechemlab.bsky.social, @bonalditiziana.bsky.social, and @rothbartlab.bsky.social. buff.ly/3GCABMr

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Oversharing: as some of you know my position is moving to a strictly computational role (and not solely proteomics), and today I’m prepping for my last digestion, using it as a way to effectively check out of lab. Can’t see it being my final final v5 FINAL time ever, but maybe. 🤷‍♂️

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📢 2027 US HUPO Association Awards — Nominations Now Open! 🏆 Celebrate excellence in proteomics — nominate a colleague or deserving leader today! 🙌 💡 Who can nominate: Current US HUPO members 📅 Deadline: October 2, 2026 🔗 Learn more & submit your nomination: us-hupo.org/awards #USHUPO #Proteomics

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