George Galea
georgegalea.bsky.social
Researcher in Pepperkok team @EMBL, Heidelberg. All about big data, high-throughput screening, Golgi DNA damage response & endomembrane-nuclear communication
👤 Joined on 11 November 2024
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- 11 Kas 2024, 14:48
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
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Excited to share our paper, now out in @jcb.org! 🎉 Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb.... 📷by me ❤️
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In @jcb.org, @georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al reveal that RAD51C is anchored at the Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...
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@georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al. reveal that RAD51C is anchored at the #Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...
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The findings of a study by @georgegalea.bsky.social et al. emphasize the importance of spatial regulation of DDR proteins for the maintenance of genomic integrity and cellular homeostasis, and suggest a broader role for the Golgi apparatus as a regulatory platform in DNA repair. rupress.org/jcb/ 1/3
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Congratulations, I love this discovery! I’d also love to see it citing, in its final version, our finding doi.org/10.15252/emb..., it’s important when considering how few works connect the nucleus with the Golgi… thank you!
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