Welcome to the UK DNA Replication Meeting 2026! We’re delighted to be in Nottingham for three days of exciting science, discussion and networking focused on the mechanisms that faithfully replicate and maintain our genomes.

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👏 Fantastic to see the first of @biofair.bsky.social's Pathfinder Projects announced! The projects are a critical first step in a coordinated, UK-wide infrastructure to make complex biological data more accessible, reusable, and AI-ready for researchers everywhere. #FAIRdata #lifescience

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The project initially focuses on potatoes, a globally important crop, with the goal of developing technology pipelines to fast-track #plantengineering. Find out more here - www.earlham.ac.uk/research-pro... @cgrandel.bsky.social @conradn.bsky.social

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Finally, we map initial DNA unwinding genome-wide at near base-pair resolution. We found that strand separation initiates at the interface between opposing MCM2-7 hexamers, capturing this transient step of helicase activation in vivo for the first time.

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New preprint🎉 Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated. 👉 doi.org/10.64898/202...

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