Mittal Group @ TAMU

mittalgrouptamu.bsky.social

30 September 2026 17:39

(Part 2/2) Combining NMR experiments with MD, we show how RNA engages both the LC and RGG1 domains of FUS through a diverse interaction network involving Arg, Tyr, Gln, and other residues. Surprisingly, RNA also accelerates the liquid-to-solid transition of FUS condensates.

Mittal Group @ TAMU

mittalgrouptamu.bsky.social

17 September 2026 21:14

(Part 1/2) Excited to share our latest paper (doi.org/10.1063/5.03...), led by PhD student Shuo-Lin Weng and Dr. Shiv Rekhi! We introduce buffered Charge-Regulation Monte Carlo method to model dynamic charge regulation, buffer equilibria, and ion partitioning within condensates.

Mittal Group @ TAMU

mittalgrouptamu.bsky.social

17 September 2026 21:14

(Part 2/2) We show that condensates establish sequence-specific pH gradients toward their isoelectric points: alkaline for FUS and acidic for PGL-3. Buffer depletion further shows that dynamic charge regulation shapes condensate electrochemical microenvironments.

Samrat Mukhopadhyay

samratmukhopadhyay.bsky.social

09 August 2026 10:09

20 years ago (August 2006): During my postdoc @scripps.edu, I presented a poster on my ongoing/unpublished work at the @proteinsociety.bsky.social meeting in San Diego. The paper was published in @pnas.org in February 2007 (cited ~ 370). This was the first single-molecule FRET study of an IDP/prion.

Biophysical Society

biophysicalsoc.bsky.social

09 August 2026 03:52

The #bps2027 Biophysical Society Lecturer is Susan Marqusee, University of California, Berkeley. Don't miss her talk, "Touring the Energy Landscape" at the Annual Meeting in Philadelphia on Monday, February 22. See you there!