fmattiroli.bsky.social
Biochemist with a love for chromatin. Group leader at the Hubrecht Institute.
👤 Joined on 11 October 2023
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@fmattiroli.bsky.social🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...
Show PostHow can histone acetyl-transferase acetylate a specific histone tail residue ? Using cryo-EM, we captured the MSL complex in a stable post-catalytic state, visualising the acetyl group on H4K16, a central mark for gene regulation authors.elsevier.com/sd/article/S...
Show PostSuper-excited 🤪 for SPIN-seq! Congrats to Jagadish, Becky, and team! We link the worlds of single-molecule kinetics 🔬 and single-molecule sequencing 🧬 - on the *same* single molecules, surface and instrument! Single-molecule phenotyping + in situ sequencing = SPIN-Seq. www.nature.com/articles/s41...
Show Post🚨🚨Preprint alert!🚨🚨 We removed the main centromere 3 domain of Drosophila‼️ We designed an inducible dCas9-Fok1 system to cut 🧬 at unique sequences flanking the ~50-kb island where most of CENP-A sits. To our knowledge, this has never been attempted in a living animal!
Show Posthappening this afternoon at Cold Spring Harbor: meetings.cshl.edu/meetings.asp... one former and one current member of the lab, giving talks back to back. Couldnt be prouder, but honestly cant take any credit.... #womeninSTEM
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