Sjors Scheres

sjorsscheres.bsky.social

18 October 2026 10:07

PS: These are my own, personal opinions, not the ones of my employer. I express them because I care deeply about how science is done and I am worried the UK is turning into the wrong direction.

Sjors Scheres

sjorsscheres.bsky.social

18 October 2026 10:07

Changes are being made very rapidly, and I hope that politicians like @chrismcdonaldmp.bsky.social and @chionwurah.bsky.social will have time to scrutinize them carefully. One would not want a power grab by the civil service to damage UK innovation.

Sjors Scheres

sjorsscheres.bsky.social

18 October 2026 10:07

However, ongoing reforms in @ukri.org seem to threaten this very concept. Instead of promoting the exploration of novel research paths, it seems obsessed with bureaucracy, in its own ranks, and (much worse) in forcing this down onto the scientists.

Sjors Scheres

sjorsscheres.bsky.social

18 October 2026 10:06

This in @nature.com makes great points on how to enhance scientific creativity. In the UK, core-funded institutes have been very successful in this. The long-term funding allows much higher risk taking and reduced administrative burdens protect time for deep work. www.nature.com/articles/s41...

Matteo Doudin

matteodoudin.bsky.social

16 October 2026 21:10

How can histone acetyl-transferase acetylate a specific histone tail residue ? Using cryo-EM, we captured the MSL complex in a stable post-catalytic state, visualising the acetyl group on H4K16, a central mark for gene regulation authors.elsevier.com/sd/article/S...