Fulcrum Genomics

fulcrumgenomics.com

21 October 2026 12:41

Interested in methylation sequencing and alternative sequencing platforms? Find @nilshomer.com and @yfarjoun.bsky.social in the #ASHG2026 poster hall! UMI-aware methylation sequencing Sequence context and variant-calling accuracy Oct. 21 2:30–4:30 p.m. EDT Bring your toughest bioinformatics problem.

Rob Patro

robp.bsky.social

14 October 2026 17:09

Got to share some recent (& ongoing) work with folks at @fulcrumgenomics.com yesterday! Instead of my normal style (go deep on 1 project), I covered 3 recent projects: github.com/COMBINE-lab/... github.com/COMBINE-lab/... github.com/zrudnick/bra... Thanks for inviting me to meet with the team!

What's worse than a drive-by pull request from some rando with no interest in your project who merely pointed their AI at one of your open issues? That same drive-by PR, but when the issue reporter (and their cybernetic friend) has already opened a superior PR fixing the problem.

Matt Holt

holtjma.bsky.social

28 August 2026 05:21

Lastly, the tool is blazing fast and easy to use! I’m personally very proud of how it turned out from a usability perspective. The tool is fully open source (github.com/PacificBiosc...), so give it a try if you’re doing benchmarking! 4/N

Rob Patro

robp.bsky.social

28 August 2026 05:20

While we are still working on the first feature/perf full release of the rustar-aligner, you can currently use the main branch to build a byte-compatible STAR index >2x faster with <1/2 of the RAM (and use it with STAR). Plus it fixes a small STAR bug github.com/scverse/rust...