Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!

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Depending on the yarn and fibers, a hand-knit sweater can be uniquely beautiful in a way that's not easily replicated by machine-made counterparts. Hand-knitting can result in a slightly uneven texture, which adds visual interest to an outfit. Machine-made knits can be quite flat in comparison.

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A telomere-to-telomere map of somatic mutation burden and functional impact in a cancer www.cell.com/cell/fulltex...

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Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome www.cell.com/cell/fulltex...

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The same cell identity can conceal a different developmental history. Our new preprint connects cellular ancestry, fate timing and gene expression in mouse embryos and stem cell-derived embryo models. doi.org/10.64898/2026.… @Rachsuliusy @_Choi_Junhong

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