Rb is a dual-function transcriptional regulator that, although enforcing cell cycle arrest, can also activate programs that counteract its tumour suppressor function @nature.com @petermaccc.bsky.social @shomgoel.bsky.social www.nature.com/articles/s41...

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CDK4/6 inhibitors, a cornerstone treatment for advanced HR+ breast cancer, were thought to work by reactivating Rb, a tumor suppressor that puts the brakes on cancer cell growth. In @nature.com, ASPIRE Awardee @shomgoel.bsky.social shows that isn’t the full story. www.petermac.org/about-us/new...

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The prevalence of #Genitourinary Syndrome of #Menopause in patients with a history of #BreastCancer is high. In this short video Dr. Letícia Varella discusses #VaginalEstrogen use in patients with a history of breast cancer.

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very important (but negative) trial on cdk46i in mTNBC. huge shout-out to @stolaney1.bsky.social and Shom Goel for conducting this trial👍 @oncoalert.bsky.social #bcsm

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After CDK4/6 Inhibitors: Advancing Treatment for HR+HER2-negative Metastatic Breast Cancer— Mafalda Oliveira, Erica Mayer, and Shom Goel will address this topic in an educational session at #SABCS25 (December 9-12). Learn more: buff.ly/0YYiXTa

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