Today in CellCellPress 🥂collaborating across 3 continents to study how organisms at the extremes use RNA modifications, discovered the first natural modification of the RNA backbone, phosphorothioates and their writers. @SchragaSchwartz & several archaeal labs-thanks for being part of the team !

Maria Hondele

mariahondele.bsky.social

18 September 2026 19:26

The heatwave is finally over - just in time for our “Frosty Foci” to finally come online! ❄️🦠 We found that E. coli builds a transient nucleolus-like ribosome biogenesis compartment during cold adaptation, when RNA (mis)folding makes ribosome biogenesis challenging.

RNA modification papers

rnamod.bsky.social

18 September 2026 19:25

RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation The Journal of biological chemistry · Shimanski et al. doi.org/10.1016/j.jbc.2026.113573 #RNAsky #RNAmods

RNA modification papers

rnamod.bsky.social

18 September 2026 19:25

Transcript-wide m6A methylation defines the efficiency of cap-independent translation initiation RNA (New York, N.Y.) · Smolin et al. doi.org/10.1261/rna.081017.126 #RNAsky #RNAmods

eLife

elife.bsky.social

17 September 2026 13:49

FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall