Lipids alone define more than 500 biochemical territories with distinct compositions, which we call lipizones. #SpatialOmics #MassSpectrometryImaging

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Lipizones follow neither cell-type nor anatomical boundaries. The same lipizone can extend from a neuron's cell body to its distant axon terminals, or cut across several cell types sharing a location, capturing relationships that a map built around cell bodies would miss.

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In our analyses, gene expression predicts only part of this landscape, so membrane composition has to be measured directly rather than inferred from the transcriptome.

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Lipizones also respond to physiological state. During pregnancy they are extensively remodelled across cortex and white matter, and in white matter their patterns appear to retain the order in which tracts were myelinated.

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Beyond basic biology, many neurological diseases turn out to be lipid diseases: rare ones that start from a single failing enzyme or transporter, and common ones. #neurodegeneration #RareDisease #lysosomaldisease

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