Matthieu Schapira

mattschap.bsky.social

18 August 2025 15:32

CACHE 7 is launched with support from the @gatesfoundation.bsky.social and unpublished data from Damian Young at @bcmhouston.bsky.social, Tim Willson @thesgc.bsky.social and Neelagandan Kamaria InSTEM. Design selective PGK2 inhibitors. We'll test them experimentally. bit.ly/4lnVYOs

UCL Faculty of Life Sciences

ucllifesciences.bsky.social

11 August 2025 19:51

UCL, with @thesgc.bsky.social and scientists from 30 leading organisations, has published a landmark roadmap in @natrevchem.nature.com‬, outlining a global, open science strategy to scale up hit discovery efforts for every human protein. #Target2035 #DrugDiscovery www.nature.com/articles/s41...

Aled Edwards S.G.

aledmedwards.bsky.social

23 July 2025 17:28

After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published. rdcu.be/exxi7

Matthieu Schapira

mattschap.bsky.social

24 June 2025 18:03

CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r

gsbardella.bsky.social

gsbardella.bsky.social

22 May 2025 17:39

The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs". @thesgc.bsky.social