edgePython v0.5.0 released at github.com/pachterlab/e... (`pip install edgepython`) Matches the forthcoming edgeR 5.0 with several extra features as well as some edgeR bugs avoided. Major speedups (4-6x faster, camera >100x), I/O improvements, and proper support for kallisto.

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METTL4 interacts with histone methylation readers MRG1/2 to regulate alternative splicing and promote thermomorphogenesis in Arabidopsis Cell reports · Zhu et al. doi.org/10.1016/j.celrep.2026.118162 #RNAsky #RNAmods

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Lung tumors mis-splice STAT2, a key immune gene, building a broken form that actively jams the signal rather than staying quiet. That splicing glitch associates with immunotherapy response. 🧵 #RNAbiology #RNAsky #RNAsplicing #cancer #immunotherapy @jax.org www.science.org/doi/10.1126/...

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CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @cp-immunity.bsky.social www.cell.com/immunity/ful... @washumedicine.bsky.social @nationwidekids.bsky.social @kingscollegelondon.bsky.social

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Aleph Alpha, soon to be part of Cohere, released open-weight of Kolibri. 78B parameters. 3.46B active. Up to 1M tokens of context. Built in Europe. Model: huggingface.co/Aleph-Alpha/... Tech Report: aleph-alpha.com/downloads/te...

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