New blog post! In it, I benchmark the new version of Dorado from @nanoporetech.com, which comes with new DNA basecalling models. Short version: big accuracy gains for hac, small improvements for sup. Check it out for the full results: rrwick.github.io/2025/05/27/d...

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Oxford Nanopore Should Spin Out Protein Sequencing #nanoporeconf 🧬🖥️ omicsomics.blogspot.com/2025/05/oxfo...

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FYI The peer reviewed final version of the paper is out now: doi.org/10.46471/gig... With more in GigaBlog on how it was openly reviewed and benchmarked: gigasciencejournal.com/blog/open-cy...

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So, I now officially own a MiSeq! I still need to figure out shipping and honestly, I don't know where I'll be shipping it to. But for $560 CAD, I may just resell it on ebay.

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We’ve just discovered that NovaSeq clamps keeping the glass flowcell scratch FC surface releasing tiny splinters that are sucked by the pump. Given enough time, it will clog the instrument. #illumina #lablife 🧪

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