debrajghose.bsky.social
I study how lymphocytes self-organize into multicellular structures. Also interested in how cells sense and respond to chemical gradients. Currently at UCSF. Previously at Harvard and Duke.
👤 Joined on 11 November 2024
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@debrajghose.bsky.socialWe think this may have implications for many systems with migrating cells. Autoattractants can be very useful in migration, but because they work best when short-lived they will also be hard to find in experiments, and so may exist in many more systems than previously believed.
Show PostFinally, we show how in slow-moving cells (think macrophages) a decaying autoattractant can lead to a variety of different outcomes, from clumping to leader-follower, and how a close association just shy of clumping causes the best chemotaxis.
Show PostNext, we show how a decaying autoattractant can be much more robust than a broken down autoattractant.
Show PostI have a new paper out: Communication through autoattractants can enhance and limit collective migration of immune cells journals.plos.org/ploscompbiol... We show how complex interactions emerge around a secreted attractant, and you can play with the model online: chemotaxis.org/autoattracta...
Show PostVery happy to share our review in @embojournal, where we discuss how biophysical cues coordinate cell state transitions from #embryo development to #regeneration. Thank you so much @Mech_Morph_Lab and @SandraEdwJor!! link.springer.com/article/10.1...
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