1/6 🧵 Six years in the making! Our new preprint is finally out! We used comparative single-cell transcriptomics to investigate how changes in gene expression contribute to the evolution of complex 3D structures, using Drosophila male genitalia as a model. www.biorxiv.org/content/10.6...

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Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

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Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...

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Happy to share a new lab @natureportfolio.nature.com paper, "Greening masks stability loss in drylands," led by outstanding @uarizona.bsky.social PhD candidate Wen Zhang rdcu.be/HMbVwS41yvqa

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Thank you so much, Alexis. Very kind of you. I feel very honoured and lucky. And thank you to all the Furlong lab, pass and present :)

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