We also performed an exome-wide scan for novel genes associated with misalignment... ♀️Age at Menopause: We identified KANK1 as a gene associated with later-than-expected age at menopause, suggesting a potential protective role against primary ovarian insufficiency.

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Why do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...

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Thank you to senior authors @astheeggeggs.bsky.social and @ceclindgren.bsky.social , and my co-authors Frederik Lassen, @barneyhill.bsky.social , @samvidav.bsky.social, @hannahcurrant.bsky.social !

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Thanks to co-authors İlknur Sur Erdem (co-first), @samvidav.bsky.social, Saskia Reibe, Philip Charles, Elena Navarro Guerrero, @barneyhill.bsky.social, Frederik Heymann Lassen, Melina Claussnitzer, and senior authors @astheeggeggs.bsky.social and @ceclindgren.bsky.social for their contributions!

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✨ NEW PUBLICATION ✨ We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation. Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...

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