Stephan Hirschi

Stephan Hirschi

stephanhirschi.bsky.social

👤 Joined on 25 November 2024

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  • 25 Kas 2024, 08:48
    🎉 Bluesky'e katıldı - İlk kullanıcı adı: @stephanhirschi.bsky.social

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How do antibodies against PfRIPR act to impede erythrocyte invasion? In our latest study, we isolate and structurally characterise a panel of human antibodies and the growth inhibitory antibody RP.012, revealing an unexpected story of synergy and antagonism that has consequences for vaccine design.

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Check out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.

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Universität Bern
16 December 2025 10:15

Die Prof. Dr. Max Cloëtta Stiftung unterstützt Stephan Hirschi dabei herauszufinden, wie der Malaria-Erreger lebenswichtige Nährstoffe aus menschlichen Zellen stiehlt, um zu überleben. Mit seiner Forschung könnte er dazu beitragen, neue Ansätze im Kampf gegen Malaria zu entwickeln. 🔗 sohub.io/49zl

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Pleased to share our review on two key families of proteins in the 𝘗𝘭𝘢𝘴𝘮𝘰𝘥𝘪𝘶𝘮 arsenal: pfEMP1 and RIFINs. Both of these fascinating families facilitate immune evasion and survival within the human host during a malaria infection.⁣ ⁣ Read here: ⁣ kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

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Congratulations to Kuang-Ting Ko (Higgins Lab) on passing her viva! Her thesis title is "Structural Characterisation of Antigens for Malaria Transmission-Blocking Vaccines", and her examiners were Andrew Blagborough (Cambridge University) & Clinton Lau (@BiochemOxford).

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