Just a periodic reminder: RNA abundance ≠ transcription activity. RNA abundance is also regulated by RNA degradation.

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Beyond excited to share the first preprint from my lab! Led by Ben Pockrass (who just won the junior investigator competition at NACFC last week for this work) we set out to identify targetable translational control elements within the CFTR 5' UTR - highlights to follow! doi.org/10.64898/202...

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Very happy to see this work out in Cell Reports! Led by Ana Morao, who was the driving force behind the project from beginning to end. Great collaboration between @pasteur.fr, @ercanlab.bsky.social at NYU, and Legnini lab @ilegnini.bsky.social at Human Technopole. www.cell.com/cell-reports...

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Don't miss the first session of the RNA Club course!! 21 Oct, 4:30 PM, Sanger Building @cambiochem.bsky.social Talks by Haopeng Yu ( @thesainsburylab.bsky.social ) and Ainan Geng ( @chemistrycambridge.bsky.social ) on RNA-binding protein recognition and thermodynamic prediction of RNA activity.

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5/5 We don’t yet know the mechanism. But the lesson is simple: a fluorescent reporter calibrated in one physiological condition cannot automatically be assumed quantitative in another. Preprint: www.biorxiv.org/content/10.6...

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