Genes & Diseases Journal

genesndiseases.bsky.social

17 December 2025 12:46

Scientists at @universityofky.bsky.social highlight how #tumor-derived exosomal PD-L1 promotes immune escape and resistance to PD-1/PD-L1 therapies, proposing #CalciumSignaling inhibition to reduce exosomal PD-L1 secretion. #OpenAccess: doi.org/10.1016/j.ge...

The National Breast Cancer Coalition

nbccstopbc.bsky.social

17 December 2025 12:45

We want to hear from you! What issues do you believe NBCC should take on as priorities for our grassroots advocacy? Learn more and send proposed priorities that advances our mission to end breast cancer here: https://nbcc.info/4aCzXtV

Signal Transduction and Targeted Therapy

sigtrans-sttt.bsky.social

17 December 2025 12:44

#OncostatinM induced by STAT5-activating #oncogenes triggers STAT-3-mediated proinflammatory signaling, resulting in #MetabolicReprogramming, enhanced cytokine secretion, and recruitment of #Immunosuppressive myeloid cells in blood malignancies. #OpenAccess: doi.org/10.1038/s413...

Genes & Diseases Journal

genesndiseases.bsky.social

17 December 2025 12:42

ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer. #OpenAccess: doi.org/10.1016/j.ge...

Genes & Diseases Journal

genesndiseases.bsky.social

07 December 2025 15:48

IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky #OpenAccess: doi.org/10.1016/j.ge...