Conservation and divergence in the allosteric architectures of five human protein kinases. Excited to share our new preprint by @carlafolgado.bsky.social @tonibeltran.bsky.social @sangerinstitute.bsky.social @crg.eu @ibv-csic.bsky.social www.biorxiv.org/content/10.6...

Show Post

1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...

Show Post

Mafalda Dias es finalista del premio Vanguardia de la Ciencia. Su línea de investigación está ayudando agilizar el diagnóstico de enfermedades raras, ofreciendo una evidencia adicional para médicos que ya tienen sospechas sobre ciertos genes implicados según los síntomas. ¡Vota ahora!

Show Post

popEVE is out in Nature Genetics! 🎉 We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders. rdcu.be/eRu7K

Show Post

New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:

Show Post