Michael Jendrusch
mjendrusch.bsky.social
(he/him) protein design @ DKFZ. Protein ML person, mathematics & science enthusiast. developer of salad paper: https://www.nature.com/articles/s42256-025-01100-z salad: https://github.com/mjendrusch/salad flexcraft: https://github.com/mjendrusch/flexcraft
👤 Joined on 26 November 2023
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- 26 Kas 2023, 15:55
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@mjendrusch.bsky.social
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BFVD v3 contains 5.8M viral protein structures, 16× more than v2; 75% high quality, filling a major gap in AFDB coverage. It fully covers 72.6% of reference proteomes and spans 72.7% of ICTV species. Great work by @eunbelivable.bsky.social et al. 📄 www.biorxiv.org/content/10.6... 🌐 bfvd.foldseek.com
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getting close to recreating Jane Richardson's style 😎
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1/ Binder ≠ inhibitor. Most PPI inhibitor campaigns find a binder first, then hope it blocks the target protein-protein interaction. We built a system that skips the hoping and selects directly for disruption of a pre-formed PPI. Meet PANCS-Inhibitors. 🧵 www.biorxiv.org/content/10.6...
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I honestly wish the folks developing AI protein design and structure prediction tools would learn how to FORMAT A FRICKING MMCIF FILE correctly.
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Programming protein shape as an explicit design layer via CAD blueprint-guided diffusion [new] ...enables precise engineering of diverse protein architectures and shape-encoded functions, including molecular swimmers.
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