Julien Klimmt
julien-klimmt.bsky.social
Postdoc @PaquetLab using novel stem-cell-derived 3D brain tissue models to study Alzheimer's disease
👤 Joined on 17 November 2024
305
Followers
84
Following
5
Total Posts
📜 Kullanıcı Geçmişi
- 17 Kas 2024, 15:57
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@julien-klimmt.bsky.social
🚫 Blokladığı Kullanıcılar
❤️ Beğendiği Gönderiler
🧠 Ein Team um @paquetlab.bsky.social vom @isd-research.bsky.social des @lmu-klinikum.bsky.social hat ein neuartiges 3D‑Gewebemodell entwickelt, das die komplexen Zusammenhänge im Gehirngewebe bei #Alzheimer real abbildet. Das könnte die Erforschung der neurodegenerativen Erkrankung voranbringen.
Show Post
None of this would have been possible without an amazing team, especially first authors @julien-klimmt.bsky.social @carolinacgoncalves.bsky.social and wonderful collaborators, including from @lmu.de @dzne.science @tum.de @bmc-lmu.bsky.social @mpi-psychiatry.bsky.social ! Many thanks!
Show PostHuge thanks also to our funding sources! @synergy-munich.bsky.social @brightfocus.bsky.social @afi-ev.bsky.social @dfg.de CoEN BMBF MKW.NRW 11/11
Show PostTogether, 3BTMs provide a reproducible, scalable and physiologically relevant platform to study human brain tissue, mature microglia and neurodegenerative disease mechanisms, and to test therapeutic interventions in a fully human system. 9/11
Show PostAs a translational proof of principle, we induced dense-core plaque-like pathology using synthetic Aβ42 and treated with Aducanumab, which engaged Aβ, reduced plaque load over time, and increased microglial Aβ phagocytosis. Multi-omics showed reversal of disease-associated glial signatures. 8/11
Show Post