haselbachlab.bsky.social
cryo EM enthusiasts with interest in molecular machines.
👤 Joined on 03 December 2023
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@haselbachlab.bsky.socialOur paper on apoptotic chromatin compaction is out now! Take a look in @embojournal.org, where we investigate compaction in living and dying cells, and show that histone deacetylation prevents DNA from spilling into extracellular vesicles in apoptosis @gerlichlab.bsky.social @imbavienna.bsky.social
Show PostResearchers in #ScienceAdvances have demonstrated that brief physical contact between healthy and bleached coral can restore algae to the bleached coral, leading to their full recovery. https://scim.ag/4ilLAZq
Show Post1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion. At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria? New preprint: yes, straight from the raw particle images👇
Show PostLoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com
Show Post🔬 Understanding how #cryoEM images are formed and what information they contain can help assess data quality, recognize acquisition artifacts, and make more informed processing decisions.
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