Joel Boerckel

jboerckel.bsky.social

25 March 2026 22:45

Impossible to overstate how timely the @orssociety.bsky.social meeting feels, again, this year. Cannot wait to see dear friends and hear exciting science. Keep an eye out for these amazing scientists at #ORS2026 this week: @cpane94.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social

Joel Boerckel

jboerckel.bsky.social

05 February 2026 12:48

This sounds like a job for @cpane94.bsky.social, the mouse personal-trainer

Joel Boerckel

jboerckel.bsky.social

16 December 2025 13:28

Together, these data show that lack of fetal movement impairs skeletal development, but this can be rescued by timed maternal exercise. We are excited about this as a model system to study mechanobiology of development that may have therapeutic impact in human fetal akinesia.

Joel Boerckel

jboerckel.bsky.social

16 December 2025 13:28

Lastly, we performed a final experiment to isolate the effects of mechanical loading, per se. We cultured explanted forelimbs of wild-type and Spd mice in a bioreactor for direct, dynamic mechanical. We found that dynamic loading restored joint morphogenesis ex vivo.

Joel Boerckel

jboerckel.bsky.social

16 December 2025 13:28

Using a mouse model of fetal akinesia, the muscle-less Spd embryo, we found that maternal exercise rescues both bone and joint development, and prevents disuse-induced resorption of the deltoid tuberosity, a hallmark of mechanoregulated morphogenesis.