Key point: Clinical and preclinical data support three potential antiseizure mechanisms of action of soticlestat. doi.org/10.1111/epi.... #epilepsy #ILAE #24Shydroxycholesterol #cholesterol24hydroxylase #glutamate #seizures #soticlestat

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We're still accepting submissions for our next special issue: Cell Biology of the Nucleus Guest edited by Abby Buchwalter and JCS Editor Megan King. Submission deadline: 3 November Find out more: journals.biologists.com/jcs/pages/nu... #CellBiology #Nucelus #Cells #Biology #Academia #Research

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It's #FluorescenceFriday! Here goes one image showing pathological Tau🟢 spreading in the monkey hippocampus. Neurons in 🟢 are dying, and healthy neurons in 🟣. Pathology spreads in a prion-like manner in this novel monkey model of Alzheimer we developed. How do we know that?

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A touch of blue velvet LUT with this #FluorescenceFriday GCaMP8 astrocytic activities at the 2p

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Posting this nice two-photon imagine of GCaMP8f in astrocytes for #fluoresencefriday 🧪 Credit - @astroantho.bsky.social

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