Our work on the basins of attraction of repulsive soft spheres is out in PNAS! We show that, contrary to popular belief, careful integration of steepest descent is tractable even for thousands of spheres... And that there is no free lunch in energy landscape studies. www.pnas.org/doi/10.1073/...

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🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

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Protein Crowding Buffers Membrane Fluidity https://www.biorxiv.org/content/10.64898/2026.10.14.759024v1

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Annoyingly, I was wrong. The modal number of citations to a political science article *is* zero. The data back it up. But the good news is, that's not that meaningful of a statement. Read on 👇 tompepinsky.com/2026/10/18/t...

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Protruding Geometry Provides Potential Homing Sites of Circulating Tumor Cells https://www.biorxiv.org/content/10.64898/2026.10.16.759535v1

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