Matt Howard

matthewkhoward.bsky.social

19 October 2026 20:10

🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

Mihaly Badonyi

mbadonyi.bsky.social

19 October 2026 18:27

How do computational predictors compare with experimental assays (MAVEs) for variant classification? Across five hereditary cancer genes, MAVE scores were more conservative (fewer pathogenic calls) yet more decisive (fewer indeterminate calls) after ACMG/AMP calibration. doi.org/10.1186/s130...

Brunilda Balliu

brunildaballiu.bsky.social

21 April 2026 22:53

1/ Our new paper is out today in @NatureComms 🎉 We mapped single-cell eQTLs in subcutaneous adipose tissue from 127 people with obesity, and linked them to genetic risk for 33 cardiometabolic and aging traits. www.nature.com/articles/s41...

Inigo Martincorena

imartincorena.bsky.social

15 April 2026 20:55

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Jeff Spence

jeffspence.github.io

15 April 2026 18:03

An absolutely beautiful line of work both scientifically and in terms of human impact.