voegtlelab.bsky.social
Vögtle Lab @ ZMBH Heidelberg We study how mitochondria build, maintain and protect their proteome - from protein biogenesis to quality control and stress responses.
👤 Joined on 05 March 2025
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@voegtlelab.bsky.social🚨 Paper alert! #CIBSS researchers examined the role of mitochondrial protease ICP55, an enzyme that removes a single amino acid from proteins imported into mitochondria – and showed how important this is for the stability of protein complexes. @voegtlelab.bsky.social @degradomics.bsky.social
Show PostA single amino acid can determine the stability of an entire protein machinery - check out this new publication by SFB 1381 PIs Nora Vögtle and Pitter Huesgen, revealing how precise protein trimming by ICP55 safeguards mitochondrial protein complexes. doi.org/10.1038/s415...
Show PostHappy to share our recent discovery of an intrinsic mitochondrial surveillance pathway that activates mtUPR already under mild oxidative stress. Great collaboration with the Vögtle Lab in Heidelberg @voegtlelab.bsky.social and the Büttner Lab in Münster @buttnerlab.bsky.social
Show PostUncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt: Molecular Cell www.cell.com/molecular-ce...
Show PostHaving a fantastic time at the GBM Redox Meeting in Saarbrücken! Thanks to all speakers, participants and my co-organizer @morganlab-saarland.bsky.social for making this such an exciting and pleasent meeting #redox #redoxbiology #gbm @gbmev.bsky.social
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