Ben Lehner

benlehner.bsky.social

03 August 2026 18:06

1st genome sequenced (Sanger 1977), 1st genome synthesised (Venter 2003), 1st genome + proteome fully mutated (Huijin Xiangua 2026!) @crg.eu @sangerinstitute.bsky.social Complete Mutagenesis of the Genome and Proteome of ΦX174 www.biorxiv.org/content/10.6...

Inigo Martincorena

imartincorena.bsky.social

18 April 2026 06:36

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Atlas of Variant Effects Alliance

varianteffect.bsky.social

28 March 2026 09:14

Opening the second day of talks at MSS 2026 is Prof. Matthew Hurles of the Wellcome Sanger Institute. His talk, 'Scaling MAVEs: Is this the end of the beginning?' discusses progress in efforts to deliver MAVEs at scale. #VariantEffect26 #MAVEs #AtlasOfVariantEffectsAlliance

Atlas of Variant Effects Alliance

varianteffect.bsky.social

28 March 2026 09:14

Our final speaker before morning coffee is Doug Fowler from the University of Washington. His talk details pathway-scale variant effect mapping in human cells with LABEL-seq. #VariantEffect26 #LABELseq ##DeepMutationalScanning #AtlasOfVariantEffectsAlliance

Atlas of Variant Effects Alliance

varianteffect.bsky.social

28 March 2026 09:14

Now, Vanessa Burns from the Wellcome Sanger Institute takes the stage to speak about saturation genome editing (SGE) to clarify variant effects within 5' UTRs of neurodevelopmental disorder (NDD) genes. #VariantEffect26 #SGE #NDD #AtlasOfVariantEffectsAlliance