I agree, and this paper of yours (bsky.app/profile/deep...) is good one on topic! (We should have cited it by the way, sorry, we will fix that...)

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This! I feel like @gquirk96.bsky.social and I've been shouting into the wind. Don't assume that original antigenic sin is why we don't make antibodies against certain drifted epitopes. Some are just inherently not antigenic, irrespective of prior immunity. www.nature.com/articles/s41...

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In new study, we show that SARS-CoV-2 has evolved decreased inherent antigenicity in humans, as quantified by a ~3-fold decrease in the number of naïve human B cells that can bind the spike RBD. doi.org/10.64898/202...

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Die seltene Lungenflechte im Toten Gebirge. (Lobaria pulmonaria)

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Vaccines, inflammation and the context of age We tend to think of vaccines in short-term terms: do they prevent disease? But some data suggest something else. Effects on cardiovascular disease and dementia appear mainly later in life. That pattern is hard to ignore. 1/3

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