stefanschoenfelder.bsky.social
Enhancers, 3D genome organisation, pluripotent stem cells Babraham Institute and Enhanc3D Genomics
👤 Joined on 25 January 2025
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@stefanschoenfelder.bsky.socialEach human (resting CD4+ T) cell has about 2 meters of DNA crammed into the nucleus. Therefore, the challenge is not just storing DNA but folding it in a way that preserves function. rdcu.be/fsd7v
Show PostThis in @nature.com makes great points on how to enhance scientific creativity. In the UK, core-funded institutes have been very successful in this. The long-term funding allows much higher risk taking and reduced administrative burdens protect time for deep work. www.nature.com/articles/s41...
Show PostHer: "OK I'll go out but I'm not drinking" Also her, two hours later:
Show PostAre weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...
Show PostBarack Obama just delivered a blistering rebuke of Trump's actions against Ilhan Omar. This is worth reading in full.
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