Matthew Aguirre

aguirre404.bsky.social

13 October 2026 14:07

Happy to share some new work done in collaboration with my colleagues in Human Genetics at Genentech! In it, we assess five model-based variant pathogenicity labels in the context of rare variant burden testing. [Summary ⬇️]. link.springer.com/article/10.1...

Communications Biology

commsbio.nature.com

13 October 2026 14:05

🧬 A GWAS of ~600,000 East Asian individuals shows that the genetic architecture of type 2 diabetes is shared with European ancestry individuals - yet population differences concentrate in specific pathways, underscoring the value of well-powered single-ancestry studies. doi.org/10.1038/s420...

bioRxiv Genomics

biorxiv-genomic.bsky.social

19 June 2026 14:42

Enhancer-gene regulatory interactions in colorectal cancer revealed through genome-wide CRISPRi perturbations https://www.biorxiv.org/content/10.64898/2026.06.05.730086v1

Mike Hubank

generoom.bsky.social

27 May 2026 09:35

Roses are red Judge Dredd is the law

Matthew Aguirre

aguirre404.bsky.social

23 May 2026 23:57

Happy to share that this is now out in Cell Genomics and a featured paper for Multi-Journal Submission from @cellpress.bsky.social — many thanks to the editorial team + our reviewers! Short recap + some further thoughts on the paper ⬇️ [1/7] www.cell.com/cell-genomic...